Calculate Trazodone Dosage for Dogs
Important: Please follow the recommended dosage and consult your veterinarian for personalized advice. The information provided is a general guideline and should not replace professional medical judgment.
Trazodone is a commonly prescribed medication for dogs experiencing anxiety, stress, or behavioral issues. This guide will walk you through the details of trazodone usage, including proper dosing, side effects, drug interactions, and how to administer it effectively. Additionally, the dog trazodone dose calculator provided will help ensure accurate and safe dosing for your canine companion.
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What is Trazodone for Dogs?

Trazodone is a type of antidepressant medication known as a serotonin antagonist and reuptake inhibitor (SARI). While originally designed for humans, veterinarians often prescribe trazodone for dogs to manage anxiety, stress, or behavioral problems. Common situations where trazodone is beneficial include:
- Separation anxiety
- Noise phobias (like fireworks or thunderstorms)
- Travel-related stress
- Veterinary visits
- Post-surgical relaxation
Trazodone works by increasing serotonin levels in the brain, promoting calmness and relaxation. It is a short-acting medication, typically taking effect within one to two hours.
How Trazodone Works in Dogs
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI), which means it primarily affects serotonin levels in the brain. Trazodone works in dogs by:
- Increasing Serotonin Levels: It inhibits the reuptake of serotonin in the brain, allowing more serotonin to remain available. This elevation in serotonin levels helps to stabilize mood and promote a sense of calmness.
- Blocking Certain Receptors: Trazodone also blocks specific serotonin receptors that can contribute to anxiety and agitation. By doing so, it helps reduce stress and creates a calming effect.
- Fast-Acting Relief: The medication typically takes effect within 1 to 2 hours after administration, making it suitable for situational anxiety, such as during thunderstorms, vet visits, or travel.
Trazodone Dosage for Dogs
Determining the correct dosage is crucial for the safety and well-being of your dog. The typical trazodone dosage for dogs is 1 to 3 mg per pound of body weight per day. However, it’s essential to never exceed 300 mg per dose and 600 mg per day, regardless of the dog’s size.
Factors Affecting Dosage
- Dog’s Weight: Dosage is calculated based on the dog’s weight. Larger dogs require higher doses, but the daily maximum limit should not be surpassed.
- Severity of Anxiety: Mild anxiety may require a lower dose, while severe stress or post-surgical anxiety might need a higher dose within the safe range.
- Health Conditions: Dogs with liver, kidney, or heart problems may require a lower dose to avoid complications.
- Concurrent Medications: If your dog is on other medications, your veterinarian may adjust the trazodone dosage to avoid interactions.
Trazodone Dosage Chart by Weight
Below is a detailed chart of trazodone for dogs. Our dog trazodone dose calculator also uses the chart below to calculate the dosage for your dog.
Dog’s Weight (lbs) | Low Dose (1 mg/lb) | Medium Dose (2 mg/lb) | High Dose (3 mg/lb) |
10 lbs | 10 mg | 20 mg | 30 mg |
20 lbs | 20 mg | 40 mg | 60 mg |
30 lbs | 30 mg | 60 mg | 90 mg |
50 lbs | 50 mg | 100 mg | 150 mg |
70 lbs | 70 mg | 140 mg | 210 mg |
100 lbs | 100 mg | 200 mg | 300 mg (Max dose) |
Note: Always start with the lowest possible dose. Please consult your Vet before administering trazodone to your dog. Our dog trazodone dose calcualtor uses the dosages based on the general guidelines only.
Maximum Dosage Guidelines
- Per Dose Limit: Do not exceed 300 mg per dose.
- Daily Limit: The total daily dosage should not exceed 600 mg, regardless of your dog’s size.
- Divided Dosing: For large doses, it’s advisable to split the total daily dose into two or three smaller doses throughout the day for better efficacy and fewer side effects.
Using the Dog Trazodone Dose Calculator

To simplify dosage calculations, use our dog trazodone dose calculator. Just input your dog’s weight and it will provide the recommended low, medium and high doses, helping ensure accurate and safe dosing.
- Input weight: Put your dog weight
- Select weight unit: Select the weight unit in the calculator
- Select condition being treated: Select the condition for which you are giving trazodone to your dog
- Results: Our trazodone calculator will give the lowest, medium and higher doses for your dogs with frequency of the dosage.
Trazodone Side Effects
While trazodone is generally safe, some dogs may experience side effects. Monitoring your dog after administering the medication is crucial. Common side effects include:
- Lethargy or drowsiness
- Gastrointestinal upset (vomiting or diarrhea)
- Disorientation or unsteady walking
- Increased panting or drooling
- Agitation or restlessness (in rare cases)
- Low blood pressure
If severe side effects occur or your dog exhibits unusual behavior, contact your veterinarian immediately.
Trazodone Drug Interactions
Trazodone may affect how other medications work, which can result in unwanted side effects. Always inform your veterinarian about any medications or supplements your dog is taking. Common drug interactions include:
- Monoamine oxidase inhibitors (MAOIs): Combining these with trazodone can lead to serotonin syndrome.
- Other antidepressants: May increase the risk of side effects.
- CNS depressants: Drugs like sedatives or tranquilizers may enhance drowsiness.
- Antifungal medications: Can alter how trazodone is processed in the body.
- NSAIDs: Can increase gastrointestinal risks.
To avoid complications, always follow the dosage recommendations and consult with your vet about any other medications your dog is on.
How to Give Your Dog Trazodone
Administering trazodone for dogs is straightforward but following the correct method ensures effectiveness and minimizes side effects.
- Consult Your Vet: Always confirm the correct dosage and frequency.
- Choose the Right Form: Trazodone is available in tablets or capsules. Select the one easiest for your dog to consume.
- Administer with Food: Giving trazodone with food can help minimize gastrointestinal upset.
- Use Treats for Easy Administration: Hide the tablet in a treat or soft food to make it more palatable.
- Monitor Your Dog: After giving the dose, observe your dog for any side effects or behavioral changes.
Conclusion
When used correctly, trazodone can be a valuable aid in managing anxiety and stress in dogs. Always consult with your veterinarian before administering the medication and use the dog trazodone dose calculator to ensure accurate dosing. Monitor your dog for any side effects and be cautious about potential drug interactions.
By understanding trazodone for dogs, proper dosing, and administration methods, you can help your dog achieve a calmer and happier state. Remember, safety comes first, so never exceed 300 mg per dose or 600 mg per day, regardless of your dog’s size.
References and Sources
- Lueck LC, Cameron S, Zidan N. Effects of trazodone administration on the neurologic examination in healthy dogs. J Vet Intern Med. 2022 Nov;36(6):2142-2148. doi: 10.1111/jvim.16536. Epub 2022 Sep 10. PMID: 36086912; PMCID: PMC9708436.
- Whole Dog Journal